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Recently, desensitization of MOR expressed in the neurons from locus coeruleus was demonstrated to result from a decrease of both number of active receptors and the affinity of residual receptors for the agonist (Williams, 2014)

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Rizzo AN, Haeger SM, Oshima K, Yang Y, Wallbank AM, Jin Y, Lettau M, McCaig LA, Wickersham NE, McNeil JB, Zakharevich I, McMurtry SA, Langout-Astri CJ, Kopf KW, Voelker DR, Hansen KC, Shaver CM, Kerchberger VE, Peterson RA, Kuebler WM, Ochs M, Veldhuizen RA, Smith BJ, Ware LB, Bastarache JA, Schmidt EP