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Animal studies show that ketamine's effects are context-dependent: it may be neurotoxic in the absence of nociception but neuroprotective in the presence of untreated pain (188)

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In humans over 70 drugs have been implicated, and most are antibacterials or NSAIDs

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In an open-label RCT ( n = 96), oral administration of melatonin tablets (3 mg/d, 1 h before sleep, for 7 days) with standard treatment, substantially improved sleep quality and blood O 2 saturation parameters in hospitalized COVID-19 patients 667

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