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TLR4 is not a known receptor for TMAO, as the mechanism by which TMAO activates TLR4 remains under investigation

SG was supported by a grant from the Department of Biotechnology, Government of India vide project no.: BT/PR7935/Med/14/1191/2006 which was sanctioned on 6 September, 2007

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Similarly, in Kctd13 (a gene within 16p11.2 CNV) haploinsufficient and knockout mice, there was an increase in RhoA expression coupled with deficiencies in synaptic signalingan effect that was ameliorated with Rhosin treatment [137]

WAT is mainly composed of large, lipid-storing white adipocytes, but also contains a complex stromal vascular fraction (SVF) with various cells like preadipocytes, fibroblasts, endothelial cells, immune cells (mainly macrophages), and mesenchymal stem cells (MSCs) [32]