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As illustrated in Figure 2, these kinases phosphorylate the plasma membrane transporters, shifting them into a state that halts inward reuptake and initiates reverse transport (efflux) mode (Underhill et al., 2020)

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If you notice a sudden change in effectiveness, increased hunger, reduced appetite suppression, or stalled weight loss , and nothing else in your protocol has changed, degraded medication should be on your list of suspects