For example, the catalytic nanosystem composed of erythrocyte membrane (mRBC)-camouflaged hollow MnO 2 (HMnO 2 ) encapsulated lactate oxidase (LOX) and glycolysis inhibitors can deplete lactate in TME and produce oxygen through LOX-catalyzed oxidation of TME, and the combination treatment of tumors with PD-L1 can successfully reverse immunosuppressive in TME by significantly reducing the number of M2 TAMs (24)
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