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After rising sharply during the COVID-19 pandemic, drug overdose deaths involving opioids declined to 83,140 in 2023, followed by a significant drop to 54,743 deaths in 2024, according to provisional data from the Centers for Disease Control and Prevention

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Enhanced mitochondrial fission, frequently observed in tumors, supports glycolysis, invasiveness, and resistance to apoptosis, 233 while impaired fusion accentuates mitochondrial and metabolic instability

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The optical density (A 600nm ) of the mycelial homogenate was adjusted to 0.5 with sterile RMM broth containing 10 mM KH 2 PO 4 , serving as the inoculum