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By reducing oxidative stress, systemic inflammation, and metabolic dysregulation, these agents may counteract key mechanisms involved in the development of DPN

Of note, even before the introduction of the newer classes of medications, multifactorial, target-driven therapies addressing glycaemic, blood pressure and lipid control that incorporated reninangiotensin system blockade, the use of statins and attention to lifestyle factors significantly reduced the progression to end-stage kidney disease by about 50% in people with type 2 diabetes, hypertension and microalbuminuria

Nature 379: 69-72, 1996

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