2015;220(Pt A):11929
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By employing a conditional gene expression strategy on an ApoE knockout background to eliminate interference from endogenous central ApoE, the study demonstrated that peripheral expression of ApoE4 alone is sufficient to induce memory impairment, BBB leakage, and perivascular gliosis, with a severity comparable to that observed in systemic ApoE4 expression models [88]
rather, within this framework, observed clinical phenomena may reflect contributions from peripheral modulation, central integration, and state-dependent processes to varying degrees across treatment stages, influencing multiple nodes including sensory, liking, and wanting, and ultimately shaping food intake and body-weight outcomes (60)
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