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If the medication is proven to have some positive health impact during this period, it may be cleared to enter the first stage of human clinical trials
Owing to oxidative damage, multiple covalent bonds in the DNA get modified, including inter and intra-strand crosslinks, strands collapse, crosslinking between proteins and DNA occurs, lesions form in single nucleobase, etc
They generally prefer to cover medications when they are used for their FDA-approved indications
Insights From Post-Marketing Studies An observational cohort study involving 50,000 pregnant women with type 2 diabetes found no significant increase in birth defects among those who took GLP-1 medications early in their pregnancies, specifically around the time they discovered they were pregnant
2000 Nov;59(4):595-600
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