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GLP-1 RAs vs

The BMI requirements for GLP-1 medications are important because these are prescription medications intended for people with clinically significant excess weight, not for cosmetic weight loss in people already at a healthy weight

Similarly, exenatide-4 inhibits hepatocarcinogenesis independent of obesity and MASH resolution, acting through the cAMP-PKA-EGFR-STAT3 axis and mTOR modulation to suppress proliferation and reduce HCC multiplicity (Zhou et al., 2017)