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The delivery of a sufficient amount of oxygen to the hypoxic site without leaking any oxygen into blood circulation had proven difficult, but hydrogels offered one route that the exogenous oxygen could be delivered in a suitable dose, directly to the target site, and activated to trigger the release of oxygen, reducing the aforementioned issues previously encountered

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Its long-term effect makes it possible to observe a gradual change over time, giving information about the immediate and the long-term metabolic reactions