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Additionally, the secondary bile acids 3-oxoLCA and isoLCA function as TGR5 agonists that suppress the differentiation of Th17 cells in vitro through two mechanisms: (1) directly inhibiting the expression of RORt, and (2) promoting the polarization of M2 macrophages, which indirectly inhibits the development of Th17 cells (119)

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Maintenance cadence: two RF sessions per week, two microcurrent sessions per week, two to three LED sessions per week, and microinfusion every two weeks if you added it in Phase 3

Peptide Therapy: GHK-Cu (copper peptide): Shown to support hair follicle growth and reduce inflammation Thymosin Beta-4 (TB-500): May improve tissue repair and follicular microenvironment Evidence Level: Preliminary

Evaluation of long acting GLP1R/GCGR agonist in a DIO and biopsy-confirmed mouse model of NASH