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The NOR test primarily relies on the perirhinal cortex, which is influenced by the hippocampus and synaptic plasticity, and is based on the natural preference of rodents to investigate novel objects over familiar ones (Antunes and Biala, 2011)
After that, if everything looks good, tests are often spaced out to every 3 to 6 months
Crystal structures of the glutamate receptor ion channel GluK3 and GluK5 amino-terminal domains
Blood work showing estradiol levels guides decision-making
These mechanisms can lead to reduced food and fluid intake, as well as gastrointestinal symptoms that may affect hydration status
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