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The Indication List Is the Thesis Here is what Lilly has publicly disclosed about brenipatides clinical program, drawn from the Q4 2025 earnings deck and the companys own trial registries
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Weight loss typically ranges from 4-8 lb during the first month, with individual variation based on starting weight and caloric reduction achieved
Reduction of chronic inflammation, which increasingly appears to drive some forms of depression, provides another avenue
54 In another phase 2 trial done to evaluate the efficacy of orforglipron in adults with obesity without diabetes, it was found to lead to significant weight reduction compared to placebo
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