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The most common side effects include nausea, vomiting, diarrhoea, decreased appetite, constipation, stomach pain, and indigestion, and these tend to be most noticeable during the initial weeks of treatment or shortly after a dose increase, typically easing as the body adjusts

In addition, GLP-1 secretion is positively correlated with postprandial bile acid concentration in healthy individuals [165]

By the second week after injection, roughly 25% of the original dose remains active, providing continued appetite suppression and metabolic benefits throughout the week

During the study period, there were 27 major adverse cardiovascular events, including heart attack and stroke, among people who received retatrutide, compared with 23 events in the placebo group

Clinical data shows average weight loss of 1-2 pounds per week during the first 3 months, with pace often slowing thereafter as the body reaches new equilibrium points