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Ann Rheum Dis (2006) 65 Suppl 3:iii89

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When melanocytes are hyperactivated by specific triggers UV radiation, post-inflammatory signals from acne or injury, hormonal changes (especially estrogen and progesterone in melasma), or genetic predisposition they produce excess melanin that accumulates in patches, creating dark spots, uneven tone and visible discolouration

Vitamin B12 is essential for nerve function, red blood cell production, and DNA synthesis

Weeks 12: Early Changes All skin types: skin may feel more hydrated and balanced with subtle improvements in tone Dry/Sensitive: reduced redness and irritation