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Frontiers in Microbiology, 12 , 639948

As shown in Table 1 [1,8,12-19] , because of the critical role of this pathway in energy regulation, functional abnormalities caused by mutations in any of its critical genes (e.g., LEP , LEPR , POMC , PCSK1 , MC4R ) can lead to severe early-onset obesity and extreme hyperphagia and are often accompanied by endocrine abnormalities due to deficiencies in related hormones, such as hypogonadism and hypothyroidism [12,20]

Our food environment drives weight gain Foods high in salt, sugar and fat that are "highly palatable and energy dense" are pretty much everywhere and our brain chemistry drives us to consume them, says Kessler

Undertaking a detailed literature review of gastrointestinal hormones he concluded there was no convincing evidence to demonstrate that duodenal mucosal extracts had any impact on blood glucose (Creutzfeldt