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In mouse models of lupus, treatment with these peptides reduced lupus nephritis severity and decreased B cell activation

Moreover, it is closely correlated to impaired levels of blood thiamine diphosphate (TDP), a crucial coenzyme of pyruvate dehydrogenase and -ketoglutarate dehydrogenase (KGDHC) enzymes allocated in the Krebs cycle (Sang et al., 2018)

Nutlin-3, 2,000 cells

Lett., 2004

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