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One mechanism that contributes to cytochrome c detachment from IMM involves cardiolipin oxidation because oxidized cardiolipin has a much lower affinity for cytochrome c than the reduced form

His initial symptoms included excessive fatigue and weight gain, followed by multisystem involvement

Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ et al (2007) RASRAFMEK-dependent oxidative cell death involving voltage-dependent anion channels

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