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However, the hyperglycemic effects of glucagon pose a challenge for its therapeutic application [77]

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Polyethylene glycol (PEG) is a water-soluble inert polymer that reduces the renal clearance of the drug and prolongs the half-life, in addition to enhancing water solubility and preventing proteolysis

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GLP-1 agonists, Cleveland Clinic (2023) Nutritional modulation of endogenous glucagon-like peptide-1 secretion: A review , Nutrition & Metabolism (2016) Closing Americas fiber intake gap, American Journal of Lifestyle Medicine (2016) Easy ways to boost fiber in your daily diet, Academy of Nutrition and Dietetics (2021) The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon, The American Journal of Physiology-Gastrointestinal and Liver Physiology (2018) Mediterranean diet effects on Type 2 diabetes prevention, disease progression, and related mechanisms

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