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Although clinical trials dont list "feeling cold" as a documented side effect of tirzepatide, patients have developed their own theories - and some make biological sense

Use of GLP-1 weight-loss medications may have mixed effects on complication risks for patients undergoing panniculectomy, according to a study published in the April issue of Plastic and Reconstructive Surger y

However, in the context of increased C-peptide levels, there are some other effects that are more relevant: Continuous infusion of GLP1 for 2 days, has been shown to be able to help prevent the death of beta cells in a rat-model of T2DM (Zucker Diabetic rats) (Farilla et al, 2002)

However, its primary use is for managing Type 2 diabetes

& Bjordal, J