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The hormone represents a sophisticated regulatory system that responds primarily to nutritional signals, and its production is tightly controlled by specific dietary and metabolic triggers rather than simple environmental factors

Further mechanistic studies suggest that IGF-1 induces IFITM2 expression through IGF-1R/STAT3 signal transduction, which ultimately affects tumor growth and metastasis (25)

Natural history of nonalcoholic fatty liver disease: a prospective follow-up study with serial biopsies

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Frisch, M