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Among these, three pivotal studies demonstrated particularly noteworthy results: The LEADER trial evaluated liraglutide (1.8 mg/day subcutaneous) in 9,340 patients, establishing a foundation for cardiovascular risk reduction with GLP-1 therapy [2]

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Effect of liraglutide on ambulatory blood pressure in patients with hypertension and type 2 diabetes: A randomized, double-blind, placebo-controlled trial

Serum metabolomics, excluding TMAO and its precursor TMA, was the best predictor (EV 12%) with demographics second, explaining 10% of circulating TMAO variance