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The cluster of fragments found to bind in the leucine pocket across both TRF1 TRFH XChem screens strongly validates the ligandability of this site and the possibility of developing potent inhibitors of the TRF1:TIN2 protein:protein interaction
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To view or add a comment, sign in Glucagon-Like Peptide-1 Receptor Agonists in Cardiovascular-Kidney-Metabolic Syndrome: Integrated Clinical Benefits Cardiovascular-kidney-metabolic (CKM) syndrome reflects the convergence of cardiovascular disease, chronic kidney disease, obesity, and diabetes, conditions that frequently coexist and amplify long-term morbidity and mortality
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