Most importantly, it has not been tested in humans, so while the findings are intriguing, there is no evidence yet that it actually works
Immunofluorescence-stained slides were imaged using a Zeiss Axioimager.M2m with an AxioCam MRm camera and the AxioVision program for imaging
But there was no comparison group, the time between injection and follow-up wasnt standardized, the authors didnt report how much the patients pain had improved, and the patients didnt even suffer from the same kind of knee pain
What they found: Cagrilintide 4.5 mg: 10.8 % weight reduction vs 3.0 % placebo (p 40 % of patients achieved 25 % weight reduction , historically unprecedented Safety profile in line with Phase 2 data Why it matters: REDEFINE 1 confirmed CagriSema as the largest body-weight signal reported in the published incretin literature to date
It is a tripeptide made of three amino acids: cysteine, glycine, and glutamic acid