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Multiple cellular changes occur following OTA exposure, which include decrease of Bcl-xL, survivin, (which lead to increases of apoptosis) and IL-2 and an increase of tumor necrosis factor alpha (TNF-)

This inappropriate use can precipitate severe side effects, including the risk of serotonin syndromea serious and potentially fatal condition characterized by an excess of serotonin in the brain

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J Biol Chem 277:4350511 Okamoto T, Akaike T, Sawa T, Miyamoto Y, van der Vliet A, Maeda H (2001) Activation of matrix metalloproteinases by peroxynitrite-induced protein S -glutathiolation via disulfide S -oxide formation

Adequate sleep, essential for the regeneration of glutathione and overall health