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Therefore, a possible mechanism proposed by the authors is that the activation of the farnesoid X receptor (FXR) by exendin-4 stimulates the expression of FGF15 in the small intestine and inhibits the expression of cytochrome P450 family 7 subfamily A member 1 (Cyp7a1) in the liver through fibroblast growth factor receptor 4 (FGFR4), thereby reducing fecal bile acid excretion and liver bile acid synthesis [75]
Specifically, semaglutide (used in Ozempic and Wegovy) was removed from the drug shortage list on February 21, 2025, and tirzepatide (found in Mounjaro and Zepbound) was also taken off in late 2024
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