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[1] [3] These effects typically diminish over time as your body adjusts to the medication

What this means for researchers now The practical takeaway is this: semaglutide is the known quantity, retatrutide is the exciting frontier, and the field will continue evolving rapidly regardless of which compound someone chooses today

"The key point is not just how much muscle, but how healthy and functional the muscle is," Neeland says, because the goal is always to gain strength, even while losing weight

Furthermore, the REWIND trial demonstrated a 12% reduction in major adverse cardiovascular events (MACE) ( p = 0.026), including among patients without established cardiovascular disease, alongside renoprotective effects evidenced by reductions in albuminuria [56]

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