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Because most adverse kidney events have occurred in patients who experience adverse gastrointestinal symptoms, such patients should have laboratory tests and discontinuation of the medication if there is acute worsening of kidney function

Brown Norway rats that did not undergo any treatment (PQ or eye drops) were also included as a healthy untreated control group

A consultation with a healthcare professional is recommended to determine whether a B12 deficiency injection is appropriate before travelling

IGF-1 elevation : raised IGF-1 levels should be monitored during treatment

That led to approval for using the medications in people with obesity