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Malic acid is a naturally occurring organic acid that acts as a crucial intermediate in the Krebs cycle (also known as the citric acid cycle)

Importantly, several phytochemicals demonstrate metabolic benefits by enhancing GLP-1/GIP signaling through DPP-IV inhibition, providing a biologically plausible route for synergistic neuroprotection in PD (Malar et al., 2020

Finally, insulin works throughout other cells in the body to decrease blood sugar levels and promote the metabolism of sugars

This is taken care of by clinical practices that use longer plans for increasing doses

GSH continues to show promise as a therapeutic agent however its specific impact on individual types of immune cells remains poorly understood (Averill-Bates, 2023)