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Secondary: Determine whether the constipation is functional (idiopathic) or due to an underlying condition

Given the Braak hypothesis and the potential for mutant S to be transferred from the gut to the CNS through the vagus nerve, early vagotomy prior to PD diagnosis, that severs the connection between the gut (particularly the colon) and the brainstem, could be considered as a disease-modifying or preventative approach to alter PD development

Geralmente comercializado sob o rtulo "apenas para fins de pesquisa" (for research purposes only), o que constitui uma zona cinzenta regulatria

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