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On the other hand, iron is a prooxidant and can increase OS in the brain by participating in Fentons reaction and contributing to the formation of reactive oxygen species (ROS)

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Long et al., 2024), including the NADPH/FSP1/CoQ10 pathway, the dihydroorotate dehydrogenase (DHODH) pathway, the GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4)/dihydrofolate reductase (DHFR) pathway, the membrane-bound O-acyltransferase 1/2 (MBOAT1/2) pathway, the peroxiredoxin 6 (PRDX6) pathway, and the 7-dehydrocholesterol (7-DHC) pathway

Recycling & Regulation Glutathione can be regenerated from its oxidized form (GSSG) back into its active state (GSH) with the help of NADPH

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