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193 Additionally, caspase-3 cleaves GSDME at its linker region, releasing an N-terminal fragment that activates pyroptosis through a mechanism similar to that of the GSDMD N-terminal domain

Interestingly, a large meta-analysis that included data from 34,043 individuals with NAFLD, who were diagnosed either with imaging studies or histological evidence and were followed over a median period of 6.9 years, suggested that there was a 64% higher risk for experiencing both fatal and nonfatal cardiovascular events vs