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Semaglutide is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

7 This is crucial as psoriasis is associated with an increased risk of cardiovascular events 8 and a patient may be taking medications that are metabolised by CYP/P-glycoprotein mechanisms

However, some patients experience side effects such as fatigue, nausea, and mild deficiencies in key nutrients due to reduced food intake

The need for additional interventions like diet and exercise is one reason why Kahan stops short of calling this drug a game changer

It is about finding the dose that provides meaningful results for your specific situation