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I mentioned in my first discussion of orforglipron (Link here: ADA Conference 2025: Orforglipron & Bimagrumab) that it requires no special dosing as it is a traditional small molecule drug

Pilot study covered on page 412-414 Long story short in the study they had 12 grams of pyruvate 1.5 grams of HCA 250 mg of carnitine split into 3 doses though the day, and lost an average of 1.5 KG a week, with 2.3 KG of fat loss, or if you arent a filthy communist 3.3 pounds of weight, and 5.06 pound of fat per week, with some calorie restriction and a draconian exercise program of 20 minutes of brisk walking, per day, every day

Improving Metabolic Health : Greater muscle mass helps improve control of blood sugar levels and reduce the risk of developing metabolic diseases