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Body composition analysis from SURMOUNT-1 revealed that tirzepatide produces both fat mass and lean mass reduction, though the ratio favors fat loss

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This finding suggests that PTEN mutations are an additional subgroup of ser/gly high GBMs, along with PSPH amplification and PSPH V116I mutation, which could benefit from (neo)adjuvant sertraline treatment

doi: 10.1074/jbc.M607955200 Summary Keywords ghrelin, ghrelin receptor (GHS-R1a), GPCR, structural biochemistry, orexigenic hormone Citation Shiimura Y, Kojima M and Sato T (2025) How the ghrelin receptor recognizes the acyl-modified orexigenic hormone

This analysis concludes that while GLP-1 agonists demonstrate significant promise, their ultimate impact depends on addressing cost, accessibility, and long-term sustainability concerns