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These models allow researchers to study both localized tissue responses and systemic biological effects associated with regenerative signaling pathways

Both play a crucial role in regulating appetite and blood sugar levels

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A 2005 study by Finkley et al

Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)