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Growth hormone therapy can induce insulin resistance, elevate fasting glucose, worsen glycemic control in diabetics or pre-diabetics, increase risk of developing type 2 diabetes with long-term use, and require medication adjustments for individuals with existing diabetes

Besides their role in inflammation, these cytokines are detrimental to the processes of fertilization and embryo development: TNF- increases the free implants adhesions and their invasiveness through its effect on matrix metallo-proteinases (157) while TGF- hinders the local immune activity by inhibiting the natural killer cells which in turn impede the development of embryos (158)

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Novo Nordisks GLP-1, sold as Wegovy or Ozempic, and Eli Lillys tirzapetide, sold as Mounjaro, are relative newcomers to the market today