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TCF4 knockdown can promote ferroptosis and increase the cisplatin sensitivity of gastric cancer cells, 197 suggesting that abnormal activation of Wnt/-catenin pathway increases ferroptosis resistance in gastric cancer cells, offering a possible therapeutic strategy for enhancing chemotherapy sensitivity in patients with advanced gastric cancer

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For erectile dysfunction specifically, cardiovascular risk assessment (including blood pressure, lipid profile, and QRISK calculation) is recommended, as sexual problems can be an early indicator of vascular disease

A small percentage have persistent symptoms that make continued treatment untenable

Dose titration and protocol changes respond to clinical data, not a fixed schedule