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Fourthly, lifestyle factors, such as diet, physical activity, smoking or other possible confounding risk factors affecting metabolism and fat accumulation, were not recorded in this study

39 ASCT1 and ASCT2, which have mainly been studied in the context of glutamine dependence, are expressed at high levels in different cancer types, 40,41,42 prompting these transporters to be considered putative therapeutic targets in cancer, with different inhibitors currently under investigation

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Few published studies use non-oral routes, so dosing data skews toward higher milligram ranges that compensate for bioavailability losses rather than reflecting the minimum effective concentration at the receptor level