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Calorie restriction for enhanced longevity: the role of novel dietary strategies in the present obesogenic environment

Moreover, microbial metabolites such as short-chain fatty acids and secondary bile acids influence thyroid hormone metabolism by regulating hepatic deiodinase activity, enterohepatic circulation, and tissue sensitivity to T 3 (Miquel et al., 2013

Emerging research suggests that a decline in glutathione levels might precede GPX4 inactivation, further weakening the antioxidative defenses, escalating lipid ROS accumulation, and driving ferroptosis [16]

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