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In a 48-week Phase 2 obesity trial, participants on the 12mg dose recorded a mean body-weight reduction of 24.2%, versus 2.1% on placebo[1]. 83% of that group lost 15% or more of their body weight, and 93% lost at least 10%[1]

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Inhibitors of angiogenesis classically prevent the expression or block the activity of pro-angiogenic factors secreted by tumor cells by targeting their receptors on endothelial cells ( Bevacizumab Bevacizumab (Avastin ) is a humanized anti-VEGF monoclonal antibody approved in combination with chemotherapy for the treatment of several advanced solid cancers (Miller et al., 2005)