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doi: 10.1016/j.canlet.2005.02.036 43 Limn-PachecoJGonsebattME

Disease states that affect intra-portal insulin levels by increasing insulin resistance causing compensatory intra-portal hyperinsulinemia or by decreasing pancreatic -cell insulin secretion causing intra-portal hypoinsulinemia results in changes to hepatic IGF-I synthesis and secretion, and consequently changes in GH levels via the negative feedback loop

J Biol Chem 279:1816918177