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Over 32 weeks, CagriSema produced HbA1c reductions of 2.2 percentage points compared to 1.8 with semaglutide alone and 0.9 with cagrilintide alone, with CagriSema statistically superior to cagrilintide

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One of the most significant of these is the activation of SIRT1, often called a longevity gene. SIRT1 helps manage insulin sensitivity and supports healthier blood sugar regulation, which is fundamental for sustained energy and preventing the metabolic strain that can lead to weight gain

Biophys J 108(1):14

On those criteria, the picture for Marek Health is mixed rather than binary