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Moreover, the mitochondrial calcium uniporter (MCU) increases mitochondrial ROS (mROS), activating the Keap1-Nrf2 antioxidant response and upregulating SLC7A11, which enhances cystine uptake and inhibits ferroptosis in PDAC [113]

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If you begin experiencing dizziness, shakiness, or confusion, your provider may reduce your metformin dose