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For example, in a clinical trial for Wegovy, 4% of adults who have type 2 diabetes and a BMI over 27 (considered overweight) developed diabetic retinopathy, a potential complication of diabetes that leads to blood vessel damage in the retina

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Within this specific population, GLP-1 RAs exhibit major reductions in BW, BMI, WC, and SBP

On the other side, the A of ECD (residues W33-R40) runs anti-parallel with the ECL3 (residues L379-T386) (Fig