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More recently, it has petitioned the FDA to block production of compounded semaglutide by placing the ingredient on the Demonstrable Difficulties for Compounding list, which excludes drugs that are too difficult to compound safely

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The FDA restricts GLP-1 agonists (semaglutide, tirzepatide, retatrutide) to prescription status because metabolic pathways, kidney function, thyroid history, and cardiovascular factors must be assessed before initiation