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2 Interactions between the GLP-1 pathway and alcohol As shown in Figure 1, the accumulated preclinical findings imply that the GLP-1 pathway modulates alcohol-mediated responses, which include the following: 1) alcohol drinking, 2) alcohol-induced behaviors and neurochemistry, 3) the motivation to consume alcohol and alcohol-seeking, and 4) relapse drinking

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Exercise training protects against aging-induced cognitive dysfunction via activation of the hippocampal PGC-1/FNDC5/BDNF pathway

Activated glial cells further release pro-inflammatory mediators and impair neuronal glucose metabolism, which may directly regulate the central fatigue circuits in the insular cortex and prefrontal cortexkey brain regions mediating the perception of fatigue and cognitive function