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Cell 157 , 15351551 (2014)

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After prolonged storage (beyond 21 days), when the ATP-content of stored RBC decreases rapidly, the total amount of released vesicular proteins increases exponentially, reaching 10 times the amount by 50 days as compared to 14 days of storage and their composition becomes comparable to that of Ca 2+ -induced vesicles (Salzer et al., 2008)