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Lipophilic drugs can cross the RBC lipid membrane by simple diffusion, while hydrophilic compounds can enter due to the aqueous channels or other membrane-facilitated or active transport systems such as Glut1 (Magnani et al., 2012)

The analyses were post-hoc, meaning they looked at the data after the trial results had already been collected

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In vitro work by Sikiric and collaborators shows BPC-157 upregulates VEGFR2 expression in endothelial cells, which stimulates angiogenesis, the growth of new blood vessels into healing tissue